Generating the Responses Immune with Honey, Saussurea costus, and Nigella Sativa in Cellular and Humoral May Resolve COVID-19?

ABSTRACT
Backgrounds: Covid-19 has become pandemic in the world, including Indonesia.
Some Indonesia Covid-19 people tried to consume Honey, Sausseria coctus, and
Nigella sativa for curing the Covid-19 disease. From many testimonies, citizen
Indonesia people with no need to take hospitalization have reported a cure if they
consumed it.
Aims: To make evidence-based medicine that Honey, Sausseria coctus dan Nigella
may cure the Covid-19
Methods: We used to post only control design and mice as an animal model. The
research divided mice into two groups, and the first group as control received PBS
as a placebo. Then the second group, we gave Honey, Sausseria coctus dan Nigella
sativa. All of the regiment enters the mouth with special sonde to reach the
gastrointestinal organ. After administration regiments a long three weeks, we
sacrificed the mice. We evaluated cellular immune responses that are Th2, Th17,
and NK cells. We check for humoral immune response, TGF-β, IL-17A, sIgA, IL-4, IL�4, B-def, and IgG.
Results: We got deference Th2 and Th17 between control with treatment group
(p=<0.05) statistically from the cellular immune response results. Then there was
no statistical difference of NK cells between the control with the treatment group
(p=>0.05). For markers, humoral immunity all has deference between control with
treatment group (p=>0.05) statistically, but one (IL-17A) have no statistical
difference.
Conclusions: We want to continue studying immune responses in humans with
COVID-19 if giving Honey, Sausseria coctus, and Nigella sativa.